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Hedgehog

结构式 货号 产品名称 CAS号
Dynarrestin 结构式
BCP44170 Dynarrestin 2222768-84-3
Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
Robotnikinin 结构式
BCP20109 Robotnikinin 1132653-79-2
Robotnikinin is an inhibitor of Shh signaling in a concentration-dependant manner.
Jervine 结构式
BCP28214 介芬胺 469-59-0
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
Saridegib hydrochloride 结构式
BCP21080 Saridegib hydrochloride 1169829-40-6
Saridegib is an orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity.
JK184 结构式
BCP21568 JK184 315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.
TAK-441 结构式
BCP20946 TAK-441 1186231-83-3
TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway.
GANT61 结构式
BCP08050 GANT61 500579-04-4
GANT 61 is a small molecule inhibitor of Gli1 and Gli2.
SAG 结构式
BCP14694 SAG 912545-86-9
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).
MK-4101 结构式
BCP18385 MK-4101 935273-79-3
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
PF-5274857 结构式
BCP06737 PF-5274857 73615-35-0;1373615-35-0
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
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