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Epigenetic Reader Domain

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Epigenetic Reader Domain

结构式 货号 产品名称 CAS号
RVX297 结构式
BCP43937 RVX297 1044871-04-6
RVX297 is a BD2 selective inhibitor of BET bromodomains. It is structurally related to the clinical compound RVX-208. It has significant implications on differential gene expression, which possibly can be further linked to the specific disease indication. It is currently undergoing phase III clinical trials for the treatment of cardiovascular diseases.
NI-42 结构式
BCP43848 NI-42 1884640-99-6
NI 42 is a high affinity BRPF inhibitor (Kd values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (Kd = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.
GSK778 结构式
BCP43559 GSK778 2451862-42-1
GSK778, also known as iBET-BD1, is a potent and selective inhibitor of bromodomain (BRD) BD1, with IC50s of 75 nM (BRD2 BD1).
CC-90010 结构式
BCP43205 CC-90010 1706738-98-8
CC-90010 is a reversible, orally active and central nervous system-penetrant inhibitor of bromodomain and extra-terminal (BET) proteins. CC-90010 is applied in the study for advanced solid tumors.
BAY-299 结构式
BCP41584 BAY-299 2080306-23-4
BAY-299 is a potent and selective BRD1 and TAF1 inhibitor (IC50 values are 6 and 13 nM, respectively).
UMB298 结构式
BCP41242 UMB298 2266569-73-5
UMB298 is a Potent and Selective CBP/P300 Inhibitor with CBP IC50= 72 nM.
SRX3207 结构式
BCP40266 SRX3207 2254693-15-5
SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively.
VZ185 结构式
BCP38781 VZ185 2306193-61-1
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
VTP50469 fumarate 结构式
BCP38003 VTP50469 fumarate 2169919-29-1
VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
LP99 结构式
BCP38006 LP99 1808951-93-0
LP99 is the First Selective BRD7/9 Bromodomain Inhibitor.
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