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DNA Methyltransferase

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DNA Methyltransferase

结构式 货号 产品名称 CAS号
GSK3685032 结构式
BCP43733 GSK3685032 GSK3685032
GSK3685032, a potent first-in-class DNMT1-selective inhibitor that was shown via crystallographic studies to compete with the active-site loop of DNMT1 for penetration into hemi-methylated DNA between two CpG base pairs.
SW155246 结构式
BCP37840 SW155246 420092-79-1
SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1) with IC50 value of 1.2 μM, displaying 30-fold selectivity for inhibition of human DNMT1 versus human or murine DNMT3A or -3B.
CM-272 结构式
BCP32745 CM-272 1846570-31-7
CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies.
Gamma-Oryzanol 结构式
BCP13528 谷维素 11042-64-1
Gamma-Oryzanol is a triterpenoid.
Lomeguatrib 结构式
BCP07818 罗米鲁曲 192441-08-0
Inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 μM in cell-free extracts from HeLa S3 cells); attenuates MGMT activity in vitro and in vivo.
Zebularine 结构式
BCP12209 扎布拉林 3690-10-6
Zebularine(NSC309132; 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM.
RG108 结构式
BCP06930 RG108 48208-26-0
RG108 is a non-nucleoside DNA methyltransferase (DNMT) inhibitor.
SGI-1027 结构式
BCP09928 SGI-1027 1020149-73-8
SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.
5-Azacytidine 结构式
BCP07496 5-氮杂胞嘧啶核苷 320-67-2
5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.
Decitabine 结构式
BCP02870 地西他滨 2353-33-5
Decitabine (NSC 127716; Dacogen; DAC)is an available nucleoside-based DNA methyltransferase (DNMT) inhibitor with IC50 of 490, 400 and 100 nM for A549, LoVo and LoVo-DX cell lines.
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