氘可来昔替尼
| CAS号 | 1609392-27-9 | 货号 | BCP30443 |
| 中文名 | 氘可来昔替尼 | ||
| 英文名 | Deucravacitinib | ||
| 中文别名 | 氘可来替尼; | ||
| 英文别名 | BMS 986165; BMS986165;BMS-986165;Tyk2-IN-4; | ||
| 分子式 | C20H19D3N8O3 | 分子量 | 425.47 |
| 生物活性 | BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM). | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| 靶 点 | JAK | ||
结构式
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