RMC-4550
| CAS号 | 2172651-73-7 | 货号 | BCP30530 |
| 中文名 | RMC-4550 | ||
| 英文名 | RMC4550 | ||
| 中文别名 | |||
| 英文别名 | RMC 4550; RMC4550; | ||
| 分子式 | C21H26Cl2N4O2 | 分子量 | 437.36 |
| 生物活性 | RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM; shows no activity against the SHP2 catalytic domain up to 10 uM, RMC-4550 is highly selective for full-length SHP2 across panels comprising 15 other phosphatases, 468 kinases, and 44 cellular targets; cancer cell lines bearing missense mutations in KRAS at G12, but neither G13 nor Q61, exhibit sensitivity to RMC-4550 (IC50<2 uM), suppresses growth and RAS/MAPK signaling in cancer cell lines with Class 3 BRAF mutations; inhibits tumor growth and RAS/MAPK signaling in xenograft models of KRASG12C-driven cancer. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Phosphatase | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！