RMC-4550 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP30530CAS号：2172651-73-7纯度：98%

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50.00 mg	￥2500.00	In-stock	购买咨询
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CAS号	2172651-73-7	货号	BCP30530
中文名	RMC-4550
英文名	RMC4550
中文别名
英文别名	RMC 4550; RMC4550;
SMILES	CC1C(C2(CCN(CC2)C3=NC(=C(N=C3CO)C4=C(C(=CC=C4)Cl)Cl)C)CO1)N
化学名称
分子式	C21H26Cl2N4O2	分子量	437.36
纯度	98%	配送	惯例下常温包邮
产品描述	RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM; shows no activity against the SHP2 catalytic domain up to 10 uM, RMC-4550 is highly selective for full-length SHP2 across panels comprising 15 other phosphatases, 468 kinases, and 44 cellular targets; cancer cell lines bearing missense mutations in KRAS at G12, but neither G13 nor Q61, exhibit sensitivity to RMC-4550 (IC50<2 uM), suppresses growth and RAS/MAPK signaling in cancer cell lines with Class 3 BRAF mutations; inhibits tumor growth and RAS/MAPK signaling in xenograft models of KRASG12C-driven cancer.