茶碱
| CAS号 | 58-55-9 | 货号 | BCP30664 |
| 中文名 | 茶碱 | ||
| 英文名 | Theophylline | ||
| 中文别名 | 二氧二甲基嘌呤;1,3-二甲基-3,7-二氢-1H-嘌呤-2,6-二酮 ;1,3-二甲基黄嘌呤 ;水合茶叶碱; 茶叶碱; | ||
| 英文别名 | Theo-24;1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione ;1,3-Dimethylxanthine;1,3-dimethyl-xanthin; | ||
| 分子式 | C7H8N4O2 | 分子量 | 180.16 |
| 生物活性 | Theophylline is a drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine. Like other methylated xanthine derivatives, theophylline is both a competitive nonselective phosphodiesterase inhibitor, which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and inhibits leukotriene synthesis, and reduces inflammation and innate immunity nonselective adenosine receptor antagonist, antagonizing A1, A2, and A3 receptors almost equally, which explains many of its cardiac effects. | ||
| 信号通路 | Protease/Metabolic Enzyme GPCR/G Protein Others Pathway | ||
| 靶 点 | Phosphodiesterase/PDE Adenosine Receptor Autophagy | ||
结构式
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