GDC0575 hydrochloride
| CAS号 | 1196504-54-7 | 货号 | BCP30767 |
| 中文名 | GDC0575 hydrochloride | ||
| 英文名 | GDC0575 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | RG7741 HCl;ARRY-575 HCl;RG 7741 HCl;ARRY575 HCl;GDC0575 HCl;GDC 0575 HCl;GDC-0575 HCl;GDC0575 monohydrochloride;GDC 0575 hydrochloride;GDC-0575 hydrochloride; | ||
| 分子式 | C16H21BrClN5O | 分子量 | 414.73 |
| 生物活性 | GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Checkpoint | ||
结构式
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