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GDC0575 hydrochloride 结构式

GDC0575 hydrochloride

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货号 :BCP30767CAS号 :1196504-54-7纯度:98%
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  • 基本信息与产品描述
CAS号 1196504-54-7 货号 BCP30767
中文名 GDC0575 hydrochloride
英文名 GDC0575 hydrochloride
中文别名
英文别名 RG7741 HCl;ARRY-575 HCl;RG 7741 HCl;ARRY575 HCl;GDC0575 HCl;GDC 0575 HCl;GDC-0575 HCl;GDC0575 monohydrochloride;GDC 0575 hydrochloride;GDC-0575 hydrochloride;
SMILES O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl
化学名称
分子式 C16H21BrClN5O 分子量 414.73
纯度 98% 配送 惯例下常温包邮
产品描述 GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
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