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CAS号 | 1196504-54-7 | 货号 | BCP30767 |
中文名 | GDC0575 hydrochloride | ||
英文名 | GDC0575 hydrochloride | ||
中文别名 | |||
英文别名 | RG7741 HCl;ARRY-575 HCl;RG 7741 HCl;ARRY575 HCl;GDC0575 HCl;GDC 0575 HCl;GDC-0575 HCl;GDC0575 monohydrochloride;GDC 0575 hydrochloride;GDC-0575 hydrochloride; | ||
SMILES | O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl | ||
化学名称 | |||
分子式 | C16H21BrClN5O | 分子量 | 414.73 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. |
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