GDC-0575

参考资料仅供科学研究，不可用于个人用途。

货号：BCP20675CAS号：1196541-47-5纯度：98%

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CAS号	1196541-47-5	货号	BCP20675
中文名	GDC-0575
英文名	GDC-0575
中文别名	GDC0575类似物;
英文别名	ARRY 575；RG-7441；GDC 0575；ARRY575；RG 7441；GDC-0575；ARRY-575；RG7441;
SMILES	O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@](N)CCC4)=C32
化学名称
分子式	C16H20BrN5O	分子量	378.27
纯度	98%	配送	惯例下常温包邮
产品描述	GDC0575（ARRY-575，RG7441）is a small molecule inhibitor of cell cycle checkpoint kinase 1 (Chk1), with potential chemosensitization activity. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. Therefore, Chk1 inhibition may sensitize tumor cells to the DNA damaging effects of certain chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that phosphorylates cdc25 phosphatases in response to DNA damage. This results in both inhibitory tyrosine phosphorylation of cyclin-dependent kinase (CDK)-cyclin complexes and cell cycle arrest, which facilitates DNA damage repair.