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GDC0575

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货号 ：BCP25421CAS号 ：2097938-64-0纯度：98%
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  • 基本信息与产品描述
CAS号 2097938-64-0 货号 BCP25421
中文名 GDC0575
英文名 GDC0575
中文别名 GDC-0575;
英文别名 GDC-0575; GDC 0575; ARRY-575; ARRY-575; ARRY575; RG7741; RG-7741; RG 7741; AK 687476; AK-687476; AK687476;
SMILES
化学名称
分子式 C17H21BrN4O 分子量 377.28
纯度 98% 配送 惯例下常温包邮
产品描述 GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective CHK1 inhibitor. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. Therefore, Chk1 inhibition may sensitize tumor cells to the DNA damaging effects of certain chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that phosphorylates cdc25 phosphatases in response to DNA damage.
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