AZD-7762

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01893CAS号：860352-01-8纯度：98%

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CAS号	860352-01-8	货号	BCP01893
中文名	AZD-7762
英文名	AZD-7762
中文别名
英文别名	AZD7762;AZD 7762;
SMILES
化学名称
分子式	C17H19FN4O2S	分子量	362.42
纯度	98%	配送	惯例下常温包邮
产品描述	AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM.