MAZ51
| CAS号 | 163655-37-6 | 货号 | BCP31595 |
| 中文名 | MAZ51 | ||
| 英文名 | MAZ51 | ||
| 中文别名 | |||
| 英文别名 | MAZ-51;MAZ 51; | ||
| 分子式 | C21H18N2O | 分子量 | 314.38 |
| 生物活性 | MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | VEGFR | ||
结构式
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