MAZ51 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP31595CAS号：163655-37-6纯度：98%

规格	价格(CNY)	是否现货	购买咨询
500.00 mg	￥3750.00	In-stock	购买咨询
1.00 g	￥6500.00	In-stock	购买咨询

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CAS号	163655-37-6	货号	BCP31595
中文名	MAZ51
英文名	MAZ51
中文别名
英文别名	MAZ-51;MAZ 51;
SMILES	CN(C)C1=CC=C(C2=CC=CC=C21)C=C3C4=CC=CC=C4NC3=O
化学名称
分子式	C21H18N2O	分子量	314.38
纯度	98%	配送	惯例下常温包邮
产品描述	MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.