ANI-7
  • 化学数据
CAS号 931417-26-4 货号 BCP31623
中文名 ANI-7
英文名 ANI-7
中文别名
英文别名 ANI 7;ANI7;
分子式 C13H8Cl2N2 分子量 263.12
  • 用途
生物活性 ANI-7 is a potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas); potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage; binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death.
信号通路 Others Pathway 
靶 点 AhR 

结构式

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