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| CAS号 | 931417-26-4 | 货号 | BCP31623 |
| 中文名 | ANI-7 | ||
| 英文名 | ANI-7 | ||
| 中文别名 | |||
| 英文别名 | ANI 7;ANI7; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C13H8Cl2N2 | 分子量 | 263.12 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ANI-7 is a potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas); potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage; binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death. | ||
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