CL2A-SN-38
| CAS No. | 1279680-68-0 | Cat. No. | BCP32728 |
| Name | CL2A-SN-38 | ||
| Synonyms | |||
| Formula | C73H97N11O22 | M. Wt | 1480.61 |
| Description | CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. | ||
| Pathways | Others Pathway | ||
| Targets | ADC Related | ||
|
A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors
Publications Citing of Biochempartner's CL2A-SN-38(CAS:1279680-68-0) |
Structure
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