hVEGF-IN-1
| CAS No. | 1637443-98-1 | Cat. No. | BCP32794 |
| Name | hVEGF-IN-1 | ||
| Synonyms | |||
| Formula | C34H43N7O2 | M. Wt | 581.75 |
| Description | hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity.hVEGF-IN-1 shows a significant specific interaction with the G-rich region within the 5′- untranslated regions (5′-UTR) of hVEGF-A mRNA and destabilizes the Gquadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM and binds to the hairpin DNA with a Kd of 21.2 μM. The G-rich sequence G774-G790 within the IRES-A of hVEGF-A’s 5′-UTR has been shown to be critical for the translation initiation activity of IRES-A. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | VEGFR | ||
Structure
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