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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
Filgotinib maleate Chemical Structure
 BCP49095 Filgotinib maleate 1802998-75-9
Filgotinib maleate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease.
MK8457 Chemical Structure
 BCP23883 MK8457 1312518-84-5
MK-8457 is a novel inhibitor of spleen tyrosine kinase (SYK) and zeta-chain-associated protein kinase 70 (ZAP70) that is being investigated as an RA treatment.
Solcitinib Chemical Structure
 BCP23893 Solcitinib 1206163-45-2
Solcitinib is a Janus kinase 1 (JAK1) inhibitor. Solcitinib may be potential useful for treatment of psoriasis，systemic lupus erythematosus, ulcerative colitis.
Ibrutinib Racemate Chemical Structure
 BCP24087 Ibrutinib Racemate 936563-87-0
Ibrutinib Racemate is the racemate of Ibrutinib.
Crenolanib besylate Chemical Structure
 BCP24113 Crenolanib besylate 670220-93-6
Crenolanib is a n orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation.
Tyrphostin AG 835 Chemical Structure
 BCP24136 Tyrphostin AG 835 133550-37-5
Tyrphostin AG 835 is an EGRF inhibitor with antitumor activities.
PD 161570 Chemical Structure
 BCP24138 PD 161570 192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
Tyrphostin RG 13022 Chemical Structure
 BCP24139 Tyrphostin RG 13022 136831-48-6
RG 13022 is a tyrosine kinase inhibitor that selectively inhibits epidermal growth factor receptor, epidermal factor-stimulated HER14 cell proliferation, and tumor growth in vivo.
Tyrphostin AG 1112 Chemical Structure
 BCP24145 Tyrphostin AG 1112 153150-84-6
Tyrphostin AG 1112 is a Bcr-Abl kinase blocker that can activate the terminal differentiation of K562 cells and the purging of Ph+ cells.
BI1002494 Chemical Structure
 BCP24161 BI1002494 1319738-39-0
BI1002494 is a potent and selective Syk inhibitor. It acts by protecting mice from arterial thrombosis and thromboinflammatory brain infarction.
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