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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
G5-7 Chemical Structure
 BCP46781 G5-7 939681-36-4
G5-7 is an orally active JAK2 inhibitor, selectively inhibits JAK2-mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for glioma study.
SC99 Chemical Structure
 BCP46780 SC99 882290-02-0
SC99 is a selective inhibitor of JAK2-STAT3 activation.
CEP-11981 Chemical Structure
 BCP46664 CEP-11981 856691-93-5
CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death.
Sunvozertinib Chemical Structure
 BCP46584 Sunvozertinib 2370013-12-8
Sunvozertinib, also known as DZD9008, is an oral, potent, irreversible, and selective EGFR tyrosine kinase inhibitor. Sunvozertinib shows activity against EGFRexon20ins and other mutations. In both cell lines and xenograft models, sunvozertinib shows potent antitumor activity. In the two ongoing phase I clinical studies, sunvozertinib was tolerated up to 400 mg once daily.
MAX-40279 hemifumarate Chemical Structure
 BCP46381 MAX-40279 hemifumarate 2388506-43-0
MAX-40279 hemifumarate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase.
FGFR2-IN-2 Chemical Structure
 BCP46362 FGFR2-IN-2 2677709-81-6
FGFR2-IN-2 is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively.
GSK215 Chemical Structure
 BCP46447 GSK215 2743427-26-9
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader.
SPP-86 Chemical Structure
 BCP46432 SPP-86 1357349-91-7
SPP-86 is a potent RET inhibitor.
SU16F Chemical Structure
 BCP46277 SU16F 251356-45-3
SU16F is a potent and selective platelet-derived growth factor receptor ß (PDGFRß) inhibitor.
AZD4205 Chemical Structure
 BCP46221 AZD4205 2091134-35-7
AZD4205 is a highly potent JAK1-selective kinase inhibitor with excellent preclinical pharmacokinetics with potential for further clinical development. JAK1 is part of the JAK1/signal transducer and activator of transcription (STAT) axis, which plays an important role in tumour escape from EGFR-targeted treatment.
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