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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
Disitertide Chemical Structure
BCP46789 Disitertide 272105-42-7
Disitertide is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide is also a PI3K inhibitor and an apoptosis inducer.
TGFβRI-IN-3 Chemical Structure
BCP46788 TGFβRI-IN-3 2763602-67-9
TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology, inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4.
WAY-624704 Chemical Structure
BCP46784 WAY-624704 692869-38-8
WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM.
TGFβRI-IN-3 Chemical Structure
BCP46471 TGFβRI-IN-3 TGFβRI-IN-3
TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with potential application in immuno-oncology.
Ruboxistaurin mesylate Chemical Structure
BCP45743 Ruboxistaurin mesylate 192050-59-2
Ruboxistaurin mesylate is a orally active protein kinase C β (PKC-β) specific inhibitor; a salt form that is five times more water-soluble than its hydrochloride salt.
SIS3 Chemical Structure
BCP45559 SIS3 1009104-85-1
SIS3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. Smad3 Inhibitor, SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
SRI-011381 hydrochloride Chemical Structure
BCP44527 SRI-011381 hydrochloride 2070014-88-7
SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect.
Bisindolylmaleimide VIII acetate Chemical Structure
BCP43574 Bisindolylmaleimide VIII acetate 138516-31-1
Bisindolylmaleimide VIII acetate is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC.
Bisindolylmaleimide IV Chemical Structure
BCP43512 Bisindolylmaleimide IV 119139-23-0
Bisindolylmaleimide IV is an inhibitor of pyruvate phosphate dikinase (PPDK).
Belumosudil mesylate Chemical Structure
BCP41838 Belumosudil mesylate 2109704-99-4
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
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