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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
Ruboxistaurin mesylate Chemical Structure
 BCP45743 Ruboxistaurin mesylate 192050-59-2
Ruboxistaurin mesylate is a orally active protein kinase C β (PKC-β) specific inhibitor; a salt form that is five times more water-soluble than its hydrochloride salt.
SIS3 Chemical Structure
 BCP45559 SIS3 1009104-85-1
SIS3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. Smad3 Inhibitor, SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
SRI-011381 hydrochloride Chemical Structure
 BCP44527 SRI-011381 hydrochloride 2070014-88-7
SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect.
Bisindolylmaleimide VIII acetate Chemical Structure
 BCP43574 Bisindolylmaleimide VIII acetate 138516-31-1
Bisindolylmaleimide VIII acetate is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC.
Bisindolylmaleimide IV Chemical Structure
 BCP43512 Bisindolylmaleimide IV 119139-23-0
Bisindolylmaleimide IV is an inhibitor of pyruvate phosphate dikinase (PPDK).
Belumosudil mesylate Chemical Structure
 BCP41838 Belumosudil mesylate 2109704-99-4
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
D-erythro-Sphingosine HCl Chemical Structure
 BCP40404 D-erythro-Sphingosine HCl 2637-72-5
D-erythro-Sphingosine is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
HS-243 Chemical Structure
 BCP39678 HS-243 848249-10-5
HS-243 is an inhibitor of transforming growth factor-​beta kinase.
Phorbol 12,13-dibutyrate Chemical Structure
 BCP38374 Phorbol 12,13-dibutyrate 37558-16-0
Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter.
CMPD101 Chemical Structure
 BCP37871 CMPD101 865608-11-3
CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure.
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