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Protease/Metabolic Enzyme
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Ammonia Series
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- Benzene Series
Raw Materials
TGF beta/Smad
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP45743 | Ruboxistaurin mesylate New | 192050-59-2 |
Ruboxistaurin mesylate is a orally active protein kinase C β (PKC-β) specific inhibitor; a salt form that is five times more water-soluble than its hydrochloride salt.
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BCP45559 | SIS3 New | 1009104-85-1 |
SIS3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. Smad3 Inhibitor, SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
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BCP44527 | SRI-011381 hydrochloride New | 2070014-88-7 |
SRI-011381 hydrochloride is an oral bioavailabile TGF-beta signaling agonist, exhibits neuroprotective effect.
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BCP43574 | Bisindolylmaleimide VIII acetate New | 138516-31-1 |
Bisindolylmaleimide VIII acetate is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC.
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BCP43512 | Bisindolylmaleimide IV New | 119139-23-0 |
Bisindolylmaleimide IV is an inhibitor of pyruvate phosphate dikinase (PPDK).
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BCP41838 | Belumosudil mesylate New | 2109704-99-4 |
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
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BCP40404 | D-erythro-Sphingosine HCl New | 2637-72-5 |
D-erythro-Sphingosine is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
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BCP39678 | HS-243 New | 848249-10-5 |
HS-243 is an inhibitor of transforming growth factor-beta kinase.
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BCP38374 | Phorbol 12,13-dibutyrate New | 37558-16-0 |
Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter.
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BCP37871 | CMPD101 New | 865608-11-3 |
CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure.
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