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Apoptosis Pathway

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Chemical Structure Cat. No. Product Name CAS No.
Embelin Chemical Structure
BCP31134 Embelin 550-24-3
Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.
ASTX-660 Chemical Structure
BCP28730 ASTX-660 1799328-86-1
ASTX660 is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).
AT406 Chemical Structure
BCP04668 AT406 1071992-99-8
AT-406 is an orally bioavailable potent IAP of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.
MX69 Chemical Structure
BCP19296 MX69 1005264-47-0
MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
SM-164 Chemical Structure
BCP16589 SM-164 957135-43-2
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein and binds to cIAP-1 and cIAP-2 proteins. It is developed as an anticancer agent. It plays its antitumor roles through inducing degradation of cellular inhibitor of apoptosis protein (cIAP)-1/2, antagonizing X-linked inhibitor of apoptosis protein (XIAP) and inducing TNFα–dependent apoptosis in tumor cells. SM-164 is a bivalent mimetic containing two SM-122 analogues. It binds to cIAP-1 protein containing bothBIR2 and BIR3 domains, cIAP-2 BIR3 protein and XIAP protein containing both BIR2 and BIR3 domains.
AZD5582 Chemical Structure
BCP20145 AZD5582 1258392-53-8
AZD5582 is a novel class of dimeric Smac mimetics as potent IAP antagonist; binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively).
GDC-0152 Chemical Structure
BCP08767 GDC-0152 873652-48-3
GDC-0152 is a potent inhibitor of IAPs; binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K(i) values of 28, 14, 17, and 43 nM, respectively.
BV6 Chemical Structure
BCP10549 BV6 1001600-56-1
BV6 is a small-molecule Smac mimetic, which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2.
Birinapant Chemical Structure
BCP08607 Birinapant 1260251-31-7
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
LCL161 Chemical Structure
BCP07833 LCL161 1005342-46-0
LCL161 is an oral small molecule antagonist of Inhibitor of Apoptosis Proteins (IAPs) that sensitizes a subset of tumors from diverse lineages to treatment with cytotoxic therapies.