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Ion Channel/Membrane Transporter

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Chemical Structure Cat. No. Product Name CAS No.
Leptomycin B Chemical Structure
BCP35974 Leptomycin B 87081-35-4
Leptomycin B is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
Selinexor E-isomer Chemical Structure
BCP32614 Selinexor E-isomer 1421923-86-5
Selinexor trans-isomer is a trans-isomer of Selinexor or KPT-330, which is a CRM1-selective inhibitor of nuclear export.
Eltanexor Chemical Structure
BCP24993 Eltanexor 1642300-52-4
Eltanexor(KPT-8602) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
Piperlongumine Chemical Structure
BCP13030 Piperlongumine 20069-09-4
Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
Verdinexor Chemical Structure
BCP11733 Verdinexor 1392136-43-4
Verdinexor(KPT-335) is a novel, orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1(XPO1/CRM1) against canine tumor cell lines; also reduce influenza virus replication in vitro and in vivo.
KPT-276 Chemical Structure
BCP09428 KPT-276 1421919-75-6
KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Selinexor Chemical Structure
BCP08966 Selinexor 1393477-72-9
KPT-330 is an orally bioavailable selective CRM1 inhibitor.
KPT-185 Chemical Structure
BCP08195 KPT-185 1333151-73-7
KPT-185 is a selective CRM1 inhibitor.