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Raw Materials
Raf
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP46930 | KG5 New | 877874-85-6 |
KG 5 is an orally available PDGFRß and B-Raf allosteric inhibitor.
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BCP44104 | Encorafenib New | 1269440-29-0 |
Encorafenib is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells.
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BCP43938 | Rineterkib hydrochloride New | 1715025-34-5 |
Rineterkib is a RAF and ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models.
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BCP43521 | MCP110 New | 521310-51-0 |
MCP110 is an inhibitor of Ras.
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BCP43160 | Vemurafenib New | 1029872-54-5 |
Vemurafenib is a selective inhibitor of BRAF kinase that is used in the therapy of patients with metastatic and advanced malignant melanoma. Vemurafenib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe cases of clinically apparent acute liver injury.
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BCP42783 | Lifirafenib New | 1446090-79-4 |
Lifirafenib is a Novel potent and selective RAF Kinase and EGFR inhibitor.
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BCP38204 | Rineterkib New | 1715025-32-3 |
Rineterkib is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway.
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BCP34023 | Donafenib New | 1130115-44-4 |
Donafenib is an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases with potential anticancer acivity. Donafenib is under clinical trials in China in patients with advanced hepatocellular carcinoma (HCC).
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BCP31900 | AZ304 New | 942507-42-8 |
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.
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BCP31233 | Belvarafenib New | 1446113-23-0 |
Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
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