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Apoptosis Pathway
Thymidylate Synthase

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Thymidylate Synthase

Chemical Structure Cat. No. Product Name CAS No.
Nolatrexed dihydrochloride Chemical Structure
BCP02372 Nolatrexed dihydrochloride 152946-68-4
Nolatrexed dihydrochloride is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells.
Tipiracil HCl Chemical Structure
BCP06245 Tipiracil HCl 183204-72-0
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
Tipiracil Chemical Structure
BCP24231 Tipiracil 183204-74-2
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
Raltitrexed Chemical Structure
BCP02874 Raltitrexed 112887-68-0
Raltitrexed is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. Raltitrexed is used as an antimetabolite drug used in the treatment of colorectal cancer, and may be beneficial for malignant mesothelioma treatment.
Trifluridine Chemical Structure
BCP09147 Trifluridine 70-00-8
Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.
TAS-102 Chemical Structure
BCP28532 TAS-102 733030-01-8
TAS-102 is a novel oral combination drug that consists of an antineoplastic thymidine-based nucleoside analog, trifluorothymidine, and a potent thymidine phosphorylase inhibitor, tipiracil, in a 1:0.5 molar ratio.
Nolatrexed Chemical Structure
BCP12638 Nolatrexed 147149-76-6
Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity.