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Beta secretase

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Beta secretase

Chemical Structure Cat. No. Product Name CAS No.
Elenbecestat Chemical Structure
BCP39709 Elenbecestat 1388651-30-6
Elenbecestat is a novel, potent and orally bioavailable BACE1 inhibitor for the treatment of Alzheimer's disease (AD), which demonstrates prolonged reductions in plasma beta-amyloid levels after single dosing.
Atabecestat Chemical Structure
BCP25878 Atabecestat 1200493-78-2
Atabecestat, also known as JNJ-54861911, is a β-site amyloid presursor protein cleaving enzyme 1 (BACE1), an enzyme whose buildup is implicated in Alzheimer’s disease. JNJ-54861911 was found to inhibit BACE1 with approximately 2,600 nM affinity to 1 nM affinity.
Aloeresin D Chemical Structure
BCP32579 Aloeresin D 105317-67-7
Aloeresin D is isolated and purified from the herbs of Aloe arborescens Mill.
beta-Secretase Inhibitor IV Chemical Structure
BCP31596 beta-Secretase Inhibitor IV 797035-11-1
beta-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
NB-360 HCl Chemical Structure
BCP30332 NB-360 HCl 1262855-97-9
NB-360 is a potent and brain penetrable BACE-1 inhibitor.
AZD3839 Chemical Structure
BCP13212 AZD3839 1227163-56-5
AZD3839, with the potential to treat Alzheimer’s disease, was reported as a selective BACE1 inhibitor (IC50=4.8μM) for which concentration-dependent lowering of Ab peptides in cellular systems and three pre-clinical species were demonstrated.
Umibecestat Chemical Structure
BCP30325 Umibecestat 1387560-01-1
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease.
RG7129 Chemical Structure
BCP23733 RG7129 1310347-50-2
RG7129 is a potent BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM).
Sophoflavescenol Chemical Structure
BCP24815 Sophoflavescenol 216450-65-6
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.
AZD3839 Chemical Structure
BCP23892 AZD3839 1227163-84-9
AZD3839 is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
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