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Neuro Signaling Pathway
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Protease/Metabolic Enzyme
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Research Areas
- Metabolic Disease
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Pyrazole Series
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- Nucleoside Series
- Azaindazole
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- Pyridazine Series
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- Saccharide
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- Indole Series
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- Indazole Series
- Heterocyclic Series
- Pyridine Series
- Benzene Series
Raw Materials
HSP
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP24914 | ML346 New | 100872-83-1 |
ML346 is a Hsp70 activator and a Novel Modulator of Proteostasis for Protein Conformational Diseases. ML346 belongs to the barbituric acid scaffold. ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. These effects are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2.
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BCP46015 | HSP27 inhibitor J2 New | 2133499-85-9 |
HSP27 inhibitor J2 is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.
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BCP45963 | NPX800 New | 1693734-80-3 |
NPX-800 is a potent, selective, oral heat shock factor 1 (HSF1) pathway inhibitor.
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BCP27709 | Apatorsen Sodium New | 915443-09-3 |
Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
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BCP37949 | PU-H54 New | 1454619-13-6 |
PU-H54 is potent, selective Grp94 inhibitor.
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BCP42633 | Shepherdin New | 861224-28-4 |
Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.
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BCP40269 | DTHIB New | 897326-30-6 |
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM.
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BCP36508 | Retaspimycin hydrochloride New | 857402-63-2 |
Retaspimycin Hydrochloride is a potent and water-soluble inhibitor of Hsp90 with EC50s of 119 nM for both Hsp90 and Grp9.
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BCP33248 | Tamoxifen New | 10540-29-1 |
Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen activates autophagy and induces apoptosis.
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BCP31061 | JG98 New | 1456551-16-8 |
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
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