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HSP

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HSP

Chemical Structure Cat. No. Product Name CAS No.
HSP27 inhibitor J2 Chemical Structure
 BCP46015 HSP27 inhibitor J2 2133499-85-9
HSP27 inhibitor J2 is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.
NPX800 Chemical Structure
 BCP45963 NPX800 1693734-80-3
NPX-800 is a potent, selective, oral heat shock factor 1 (HSF1) pathway inhibitor.
Apatorsen Sodium Chemical Structure
 BCP27709 Apatorsen Sodium 915443-09-3
Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
PU-H54 Chemical Structure
 BCP37949 PU-H54 1454619-13-6
PU-H54 is potent, selective Grp94 inhibitor.
Shepherdin Chemical Structure
 BCP42633 Shepherdin 861224-28-4
Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.
DTHIB Chemical Structure
 BCP40269 DTHIB 897326-30-6
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM.
Retaspimycin hydrochloride Chemical Structure
 BCP36508 Retaspimycin hydrochloride 857402-63-2
Retaspimycin Hydrochloride is a potent and water-soluble inhibitor of Hsp90 with EC50s of 119 nM for both Hsp90 and Grp9.
Tamoxifen Chemical Structure
 BCP33248 Tamoxifen 10540-29-1
Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen activates autophagy and induces apoptosis.
JG98 Chemical Structure
 BCP31061 JG98 1456551-16-8
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
Alvespimycin HCl Chemical Structure
 BCP22705 Alvespimycin HCl 467214-21-7
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
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