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Protease/Metabolic Enzyme
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Chemical Structure Cat. No. Product Name CAS No.
Radicicol Chemical Structure
BCP49026 Radicicol 12772-57-5
Radicicol is an antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90). It has a role as a tyrosine kinase inhibitor, an antifungal agent and a metabolite. It is a macrolide antibiotic, an epoxide, an enone, a cyclic ketone, a member of phenols and a member of monochlorobenzenes.
DDO-5936 Chemical Structure
BCP42338 DDO-5936 2355377-13-6
DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer.
BIIB028 Chemical Structure
BCP48982 BIIB028 911398-13-5
BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity.
YUM70 Chemical Structure
BCP48933 YUM70 423145-35-1
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model.
ML346 Chemical Structure
BCP24914 ML346 100872-83-1
ML346 is a Hsp70 activator and a Novel Modulator of Proteostasis for Protein Conformational Diseases. ML346 belongs to the barbituric acid scaffold. ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. These effects are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2.
HSP27 inhibitor J2 Chemical Structure
BCP46015 HSP27 inhibitor J2 2133499-85-9
HSP27 inhibitor J2 is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.
NPX800 Chemical Structure
BCP45963 NPX800 1693734-80-3
NPX-800 is a potent, selective, oral heat shock factor 1 (HSF1) pathway inhibitor.
Apatorsen Sodium Chemical Structure
BCP27709 Apatorsen Sodium 915443-09-3
Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
PU-H54 Chemical Structure
BCP37949 PU-H54 1454619-13-6
PU-H54 is potent, selective Grp94 inhibitor.
Shepherdin Chemical Structure
BCP42633 Shepherdin 861224-28-4
Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.
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