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CDK

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CDK

Chemical Structure Cat. No. Product Name CAS No.
Inixaciclib Chemical Structure
 BCP49218 Inixaciclib 2370913-42-9
Inixaciclib is a cyclin-dependent kinase inhibitor and an antineoplastic.
Aloisine A Chemical Structure
 BCP26893 Aloisine A 496864-16-5
Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GSK-3α (IC50: 500nM), GSK-3β (IC50: 650nM), JNK (IC50~3-10μM).
Fascaplysin Chemical Structure
 BCP24646 Fascaplysin 114719-57-2
Fascaplysin is an inhibitor of cyclin D kinase 4/ cyclin D1 (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.
(-)-BAY-1251152 Chemical Structure
 BCP33291 (-)-BAY-1251152 1610358-59-2
(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-).
KB-0742 hydrochloride Chemical Structure
 BCP36919 KB-0742 hydrochloride 2416874-75-2
KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.
LY3143921 Chemical Structure
 BCP48019 LY3143921 1627696-52-9
LY3143921 is a potent and selective CDC7 kinase inhibitor.
LY3143921 hydrate Chemical Structure
 BCP48020 LY3143921 hydrate 1627696-53-0
LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.
SRX3177 Chemical Structure
 BCP48567 SRX3177 2241237-51-2
SRX3177 is a novel potent triple action inhibitor, targeting BRD, PI3K, and CDK.
GSK-3/CDK5/CDK2-IN-1 Chemical Structure
 BCP48519 GSK-3/CDK5/CDK2-IN-1 395074-72-3
GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a.
HQ461 Chemical Structure
 BCP47151 HQ461 1226443-41-9
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation.
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