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CDK

Chemical Structure Cat. No. Product Name CAS No.
CDK4/6-IN-6 Chemical Structure
 BCP46270 CDK4/6-IN-6 2380321-51-5
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
CDK5-IN-3 Chemical Structure
 BCP46220 CDK5-IN-3 2639542-32-6 
CDK5-IN-3 is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively.
(R)-CR8 Chemical Structure
 BCP45443 (R)-CR8 294646-77-8
(R)​-​CR8 (CR8) is a potent cyclin-dependent kinase (CDK) inhibitor with IC50 values of 0.09, 0.072, 0.041, 0.11, 1.10 and 0.18 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK7/cyclin H and CDK9/cyclin T, respectively. Moreover, CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
(R)-CR8 trihydrochloride Chemical Structure
 BCP45442 (R)-CR8 trihydrochloride 1786438-30-9
(R)-CR8 trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. It inhibits CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK7/cyclin H, CDK9/cyclin T and CK1δ/ε. (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect.
Dalpiciclib Chemical Structure
 BCP45155 Dalpiciclib 1637781-04-4
Dalpiciclib is a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Upon administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.
Abemaciclib metabolite M20 Chemical Structure
 BCP45076 Abemaciclib metabolite M20 2138499-06-4
CDK4/6-IN-4, the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer.
bio-THZ1 Chemical Structure
 BCP44798 bio-THZ1 1604811-14-4
bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7.
Ebvaciclib Chemical Structure
 BCP35102 Ebvaciclib 2185857-97-8
Ebvaciclib is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.
Abemaciclib Metabolites M2 Chemical Structure
 BCP42813 Abemaciclib Metabolites M2 1231930-57-6
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity.
CDK4/6/1 Inhibitor Chemical Structure
 BCP43972 CDK4/6/1 Inhibitor 2099128-41-1
CDK4/6/1 Inhibitor is a CDK4/6 inhibitor. It is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1.
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