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Raw Materials
CDK
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP46270 | CDK4/6-IN-6 New | 2380321-51-5 |
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
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BCP46220 | CDK5-IN-3 New | 2639542-32-6 |
CDK5-IN-3 is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively.
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BCP45443 | (R)-CR8 New | 294646-77-8 |
(R)-CR8 (CR8) is a potent cyclin-dependent kinase (CDK) inhibitor with IC50 values of 0.09, 0.072, 0.041, 0.11, 1.10 and 0.18 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK7/cyclin H and CDK9/cyclin T, respectively. Moreover, CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
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BCP45442 | (R)-CR8 trihydrochloride New | 1786438-30-9 |
(R)-CR8 trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. It inhibits CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK7/cyclin H, CDK9/cyclin T and CK1δ/ε. (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect.
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BCP45155 | Dalpiciclib New | 1637781-04-4 |
Dalpiciclib is a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Upon administration, dalpiciclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6). This inhibits retinoblastoma (Rb) protein phosphorylation early in the G1 phase, which prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.
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BCP45076 | Abemaciclib metabolite M20 New | 2138499-06-4 |
CDK4/6-IN-4, the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer.
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BCP44798 | bio-THZ1 New | 1604811-14-4 |
bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7.
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BCP35102 | Ebvaciclib New | 2185857-97-8 |
Ebvaciclib is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.
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BCP42813 | Abemaciclib Metabolites M2 New | 1231930-57-6 |
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity.
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BCP43972 | CDK4/6/1 Inhibitor New | 2099128-41-1 |
CDK4/6/1 Inhibitor is a CDK4/6 inhibitor. It is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1.
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