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Mdm2

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Mdm2

Chemical Structure Cat. No. Product Name CAS No.
SJ-172550 Chemical Structure
BCP45444 SJ-172550 431979-47-4
SJ-172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.
MK8242 Chemical Structure
BCP43979 MK8242 MK8242
MK-8242 is an inhibitor of MDM2 that stabilizes the tumor suppressor TP53 and induces growth arrest or apoptosis downstream of TP53 induction.
RO-5963 Chemical Structure
BCP39170 RO-5963 1416663-77-8
RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53.
PROTAC MDM2 Degrader-2 Chemical Structure
BCP36817 PROTAC MDM2 Degrader-2 2249944-99-6
PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology.
Milademetan tosylate monohydrate Chemical Structure
BCP31919 Milademetan tosylate monohydrate 2095625-97-9
Milademetan (DS-3032b) is a novel potent MDM2 inhibitor that inhibits MDM2-p53 interaction with an IC50 of 5.57 nM in the HTRF assay.
NSC-207895 Chemical Structure
BCP23434 NSC-207895 58131-57-0
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
(−)-Nutlin-3 Chemical Structure
BCP29278 (−)-Nutlin-3 548472-68-0
Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
Solasodine Chemical Structure
BCP10954 Solasodine 126-17-0
Solasodine is an antioxidant glycoalkaloid of Solanum species.
HDM201 Chemical Structure
BCP20814 HDM201 1448867-41-1
HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity.
AA-115 Chemical Structure
BCP25148 AA-115 1818393-16-6
AA-115, also known as APG-115, is a highly potent, chemically stable and efficacious MDM2 inhibitor, which has entered clinical development for cancer treatment.
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