Classified by application
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Signaling Pathways
- Angiogenesis/Protein Tyrosine Kinase
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- Epigenetics
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GPCR/G Protein
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Neuro Signaling Pathway
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Protease/Metabolic Enzyme
- Xanthine Oxidase
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Research Areas
- Metabolic Disease
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Pyrazole Series
- Quinazoline
- Nucleoside Series
- Azaindazole
- Ammonia Series
- Pyridazine Series
- Quinoline Series
- Pyrimidine Series
- Boric acid
- Pyrrole Series
- Thiophene Series
- Saccharide
- Azaindole
- Indole Series
- Piperidine Series
- Indazole Series
- Heterocyclic Series
- Pyridine Series
- Benzene Series
Raw Materials
Topoisomerase
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP46636 | Indimitecan New | 915360-05-3 |
Indimitecan is a novel topoisomerase I inhibitor.
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BCP46609 | AZD-5099 New | 907543-25-3 |
AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.
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BCP46265 | Bisantrene dihydrochloride New | 71439-68-4 |
Bisantrene Hydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
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BCP44949 | ARN-21934 New | 2230854-93-8 |
ARN-21934 is a novel potent and highly selective inhibitor for human topoisomerase II α over β.
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BCP41505 | Berubicin New | 677017-23-1 |
Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis.
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BCP41470 | Rebeccamycin New | 93908-02-2 |
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I.
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BCP40436 | Chimmitecan New | 185425-25-6 |
Chimmitecan is a potent topoisomerase I inhibitor.
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BCP36777 | Namitecan New | 372105-27-6 |
Namitecan is a potent topoisomerase I inhibitor, with antitumor property.
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BCP36302 | Exatecan mesylate dihydrate New | 197720-53-9 |
Exatecan Mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
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BCP34699 | Phenoxodiol New | 81267-65-4 |
Phenoxodiol inhibits XIAP (an apoptosis inhibitor) and DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol activates the mitochondrial caspase system and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol is a synthetic analog of Genestein.
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