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Topoisomerase

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Topoisomerase

Chemical Structure Cat. No. Product Name CAS No.
Indimitecan Chemical Structure
 BCP46636 Indimitecan 915360-05-3
Indimitecan is a novel topoisomerase I inhibitor.
AZD-5099 Chemical Structure
 BCP46609 AZD-5099 907543-25-3
AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.
Bisantrene dihydrochloride Chemical Structure
 BCP46265 Bisantrene dihydrochloride 71439-68-4
Bisantrene Hydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
ARN-21934 Chemical Structure
 BCP44949 ARN-21934 2230854-93-8
ARN-21934 is a novel potent and highly selective inhibitor for human topoisomerase II α over β.
Berubicin Chemical Structure
 BCP41505 Berubicin 677017-23-1
Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis.
Rebeccamycin Chemical Structure
 BCP41470 Rebeccamycin 93908-02-2
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I.
Chimmitecan Chemical Structure
 BCP40436 Chimmitecan 185425-25-6
Chimmitecan is a potent topoisomerase I inhibitor.
Namitecan Chemical Structure
 BCP36777 Namitecan 372105-27-6
Namitecan is a potent topoisomerase I inhibitor, with antitumor property.
Exatecan mesylate dihydrate Chemical Structure
 BCP36302 Exatecan mesylate dihydrate 197720-53-9
Exatecan Mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
Phenoxodiol Chemical Structure
 BCP34699 Phenoxodiol 81267-65-4
Phenoxodiol inhibits XIAP (an apoptosis inhibitor) and DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol activates the mitochondrial caspase system and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol is a synthetic analog of Genestein.
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