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AMPK

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AMPK

Chemical Structure Cat. No. Product Name CAS No.
IM156 Chemical Structure
 BCP44337 IM156 1422365-94-3
IM156, a chemical derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model.
BC1618 Chemical Structure
 BCP42670 BC1618 2222094-18-8
BC1618 is a novel Fbxo48 inhibitor and prevent pAmpkα degradation with MEC (minimal efficacious concentration) of 0.6 μM.
PF-06679142 Chemical Structure
 BCP40393 PF-06679142 1467059-66-0
PF-06679142 is a potent AMPK activator.
MT 63-78 Chemical Structure
 BCP38015 MT 63-78 1179347-65-9
MT 63-78 is a direct activator of AMPK, and an inhibitor of prostate cancer growth by blocking lipogenesis.
IM156 Chemical Structure
 BCP37661 IM156 1422365-93-2
IM156, a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.
ASP4132 Chemical Structure
 BCP35839 ASP4132 1640294-30-9
ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models.
Urolithin B Chemical Structure
 BCP35736 Urolithin B 1139-83-9
Urolithin B belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one). Urolithin b is considered to be a practically insoluble (in water) and relatively neutral molecule.
PF-06409577 Chemical Structure
 BCP32554 PF-06409577 1467057-23-3
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
GSK621 Chemical Structure
 BCP31970 GSK621 1346607-05-3
GSK621 is a specific and potent AMPK activator.
MOTS-c (human) Chemical Structure
 BCP31969 MOTS-c (human) 1627580-64-6
MOTS-c is a Mitochondria-derived peptide (MDP). Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK).
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