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AMPK

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AMPK

Chemical Structure Cat. No. Product Name CAS No.
Metformin Chemical Structure
BCP48284 Metformin 657-24-9
Metformin inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy.
COH-SR4 Chemical Structure
BCP46777 COH-SR4 73439-19-7
COH-SR4 is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.
BAY-3827 Chemical Structure
BCP46774 BAY-3827 2377576-35-5
BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration.
RSVA 405 Chemical Structure
BCP46773 RSVA 405 140405-36-3
RSVA-405 is a potent STAT3 inhibitor and is an analog of resveratol.
IM156 Chemical Structure
BCP44337 IM156 1422365-94-3
IM156, a chemical derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model.
BC1618 Chemical Structure
BCP42670 BC1618 2222094-18-8
BC1618 is a novel Fbxo48 inhibitor and prevent pAmpkα degradation with MEC (minimal efficacious concentration) of 0.6 μM.
PF-06679142 Chemical Structure
BCP40393 PF-06679142 1467059-66-0
PF-06679142 is a potent AMPK activator.
MT 63-78 Chemical Structure
BCP38015 MT 63-78 1179347-65-9
MT 63-78 is a direct activator of AMPK, and an inhibitor of prostate cancer growth by blocking lipogenesis.
IM156 Chemical Structure
BCP37661 IM156 1422365-93-2
IM156, a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.
ASP4132 Chemical Structure
BCP35839 ASP4132 1640294-30-9
ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models.
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