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Histone Methyltransferase

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Histone Methyltransferase

Chemical Structure Cat. No. Product Name CAS No.
WDR5-IN-1 Chemical Structure
 BCP49073 WDR5-IN-1 2408842-51-1
WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of <0.02 nM.
MM-401 Chemical Structure
 BCP25182 MM-401 1442106-10-6
MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
AM-9747 Chemical Structure
 BCP46595 AM-9747 2691869-82-4
AM-9747 is a MTA Cooperative PRMT5 Inhibitor.
MRTX1719 HCl Chemical Structure
 BCP46040 MRTX1719 HCl MRTX1719HCl
MRTX-1719 is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAPDEL SDMA cells.
EZM0414 Chemical Structure
 BCP45983 EZM0414 2411748-50-8
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay).
PF-06821497 Chemical Structure
 BCP45826 PF-06821497 1844849-10-0
EZH2 Inhibitor PF-06821497 is an orally available selective inhibitor of the histone lysine methyltransferase (HMT) enhancer of zeste homolog 2 (EZH2), with potential antineoplastic activity.
PRMT5-IN-3 Chemical Structure
 BCP45773 PRMT5-IN-3 2159123-14-3
PRMT5-IN-3 is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents.
BVT948 Chemical Structure
 BCP45529 BVT948 39674-97-0
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8 (KMT5A).
UNC6934 Chemical Structure
 BCP45445 UNC6934 2561494-77-5
UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization.
BAY-598 R-isomer Chemical Structure
 BCP44956 BAY-598 R-isomer 1906920-28-2
BAY-598 R-isomer is the R-isomer of BAY589.
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