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Signaling Pathways
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Ammonia Series
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Raw Materials
mGluR
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP44009 | LY2979165 New | 1311385-35-9 |
LY-2979165 is a metabotropic glutamate receptor agonist prodrug.
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BCP43458 | VU 1545 New | 890764-63-3 |
VU 1545 is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (EC50 = 9.6 nM, Ki = 156 nM at rat mGlu5).
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BCP39937 | LY487379 New | 353231-17-1 |
LY 487379 is a positive allosteric modulator selective for mGluR-2.
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BCP39846 | VU 0409551 New | 1363281-27-9 |
VU0409551 is a selectively glutamate receptor subtype 5 (mGlu5) positive allosteric modulator with EC50 value of 260 nM. VU0409551 shows distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling. It exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models.
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BCP38019 | VU0155094 New | 731006-86-3 |
VU0155094 is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively.
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BCP37624 | AZD-8529 mesylate New | 1314217-69-0 |
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
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BCP37625 | AZD-8529 New | 1092453-15-0 |
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
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BCP33908 | Decoglurant New | 911115-16-7 |
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.
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BCP33084 | YM 298198 Hydrochloride New | 748758-45-4 |
YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM).
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BCP33083 | NPS 2390 New | 226878-01-9 |
NPS2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors.
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