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mGluR

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mGluR

Chemical Structure Cat. No. Product Name CAS No.
DMeOB Chemical Structure
 BCP48798 DMeOB 40252-74-2
DMEOB is a negative allosteric modulator at the metabotropic glutamate receptor mGluR5.
WAY-324099 Chemical Structure
 BCP48088 WAY-324099 374548-18-2
WAY-324099 is a modulator of mGluR3; altering the lifespan of a eukaryotic organism.
LY2979165 Chemical Structure
 BCP44009 LY2979165 1311385-35-9
LY-2979165 is a metabotropic glutamate receptor agonist prodrug.
VU 1545 Chemical Structure
 BCP43458 VU 1545 890764-63-3
VU 1545 is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (EC50 = 9.6 nM, Ki = 156 nM at rat mGlu5).
LY487379 Chemical Structure
 BCP39937 LY487379 353231-17-1
LY 487379 is a positive allosteric modulator selective for mGluR-2.
VU 0409551 Chemical Structure
 BCP39846 VU 0409551 1363281-27-9
VU0409551 is a selectively glutamate receptor subtype 5 (mGlu5) positive allosteric modulator with EC50 value of 260 nM. VU0409551 shows distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling. It exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models.
VU0155094 Chemical Structure
 BCP38019 VU0155094 731006-86-3
VU0155094 is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively.
AZD-8529 mesylate Chemical Structure
 BCP37624 AZD-8529 mesylate 1314217-69-0
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
AZD-8529 Chemical Structure
 BCP37625 AZD-8529 1092453-15-0
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
Decoglurant Chemical Structure
 BCP33908 Decoglurant 911115-16-7
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.
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