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GPCR/G Protein

Chemical Structure Cat. No. Product Name CAS No.
Azelaprag Chemical Structure
BCP49627 Azelaprag 2049980-18-7
Azelaprag is an apelin receptor agonist agent candidate.
GPR81 agonist 1 Chemical Structure
BCP36389 GPR81 agonist 1 1620992-67-7
GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively.
Lotiglipron Chemical Structure
BCP49606 Lotiglipron 2401892-75-7
Lotiglipron (PF-07081532) is a Glucagon-like peptide 1 receptor (GLP-1R) agonist in development for the treatment of Diabetes Mellitus-Type 2 and Obesity.
BI-0474 Chemical Structure
BCP49602 BI-0474 2750570-55-7
BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.
BI-2865 Chemical Structure
BCP49601 BI-2865 2937327-93-8
BI-2865 is a pan-KRAS inhibitor. BI-2865 inhibited the proliferation of isogenic G12C, G12D or G12V mutant KRAS expressing BaF3 cells more potently than precursor 1 with a mean IC50 of roughly 140 nM.
Efocipegtrutide Chemical Structure
BCP49526 Efocipegtrutide 2513399-19-2
Efocipegtrutide is a long-acting glucagon, gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1) triple full agonist chemically conjugated with constant region of human immunoglobulin via non-peptidyl flexible linker.
Cotadutide Chemical Structure
BCP49521 Cotadutide 1686108-82-6
Cotadutide is a subcutaneous GLP-1 and glucagon receptor dual agonist that can be used to treat type 2 diabetes.
CVL-871 Chemical Structure
BCP49405 CVL-871 CVL-871
CVL 871 is a selective partial agonist of the dopamine D1 and D5 receptors.
CYNK-101 Chemical Structure
BCP49330 CYNK-101 CYNK-101
CYNK-101 is an investigational genetically modified NK cell therapy designed to synergize with antibody therapeutics for difficult to treat cancers of high unmet medical need.
AQST-109 Chemical Structure
BCP49308 AQST-109 AQST-109
AQST-109 is a polymer matrix-based epinephrine prodrug administered as a sublingual film that is applied under the tongue for the rapid delivery of epinephrine.
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