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Chemical Structure Cat. No. Product Name CAS No.
KU59403 Chemical Structure
BCP28847 KU59403 845932-30-1
KU 59403 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively.
ATM Inhibitor-5 Chemical Structure
BCP47340 ATM Inhibitor-5 2020089-41-0
M4076 is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.
Camonsertib Chemical Structure
BCP46512 Camonsertib 2417489-10-0
Camonsertib, also known as RP 3500, is aA Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.
M4076 Chemical Structure
BCP46441 M4076 2495096-26-7
M4076 is an ATP-competitive inhibitor of the Ataxia telangiectasia mutated (ATM) kinase with IC50 of 0.2 nM, which targets tumor cell survival and growth by inhibiting double-strand break (DSB) repair as well as checkpoint control.
SKLB-197 Chemical Structure
BCP46440 SKLB-197 2713577-16-1
SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
Gartisertib Chemical Structure
BCP44100 Gartisertib 1613191-99-3
Gartisertib is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity.
AZD6738 chiral mixtures Chemical Structure
BCP38320 AZD6738 chiral mixtures 1352280-97-7
AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
(S)-Ceralasertib Chemical Structure
BCP38319 (S)-Ceralasertib 1352226-87-9
(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.
AZ32 Chemical Structure
BCP37674 AZ32 2288709-96-4
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
BAY-1895344 hydrochloride Chemical Structure
BCP31861 BAY-1895344 hydrochloride BAY-1895344HCl
BAY-1895344 hydrochloride is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.
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