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PDGFR

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PDGFR

Chemical Structure Cat. No. Product Name CAS No.
KG5 Chemical Structure
 BCP46930 KG5 877874-85-6
KG 5 is an orally available PDGFRß and B-Raf allosteric inhibitor.
SU16F Chemical Structure
 BCP46277 SU16F 251356-45-3
SU16F is a potent and selective platelet-derived growth factor receptor ß (PDGFRß) inhibitor.
SU4984 Chemical Structure
 BCP44116 SU4984 186610-89-9
SU4984 is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM).
PD089828 Chemical Structure
 BCP37851 PD089828 179343-17-0
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
CGP-53716 Chemical Structure
 BCP34642 CGP-53716 152459-94-4
CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR.
Tyrosine kinase-IN-1 Chemical Structure
 BCP30849 Tyrosine kinase-IN-1 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
Sennoside B Chemical Structure
 BCP14631 Sennoside B 128-57-4
Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Masitinib Mesylate Chemical Structure
 BCP30695 Masitinib Mesylate 1048007-93-7
Masitinib Mesylate is a potent and selective tyrosine kinase inhibitor that targets KIT.
Olaratumab Chemical Structure
 BCP30495 Olaratumab 1024603-93-7
Olaratumab is a monoclonal antibody for the treatment of solid tumors.
Vorolanib Chemical Structure
 BCP30430 Vorolanib 1013920-15-4
Vorolanib, also known as CM-082 and X-82, is small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities.
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