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RET

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RET

Chemical Structure Cat. No. Product Name CAS No.
BT44 Chemical Structure
 BCP48539 BT44 924759-42-2
BT44 is a novel RET agonist for the treatment of experimental neuropathies.
SPP-86 Chemical Structure
 BCP46432 SPP-86 1357349-91-7
SPP-86 is a potent RET inhibitor.
TPX-0046 Chemical Structure
 BCP43814 TPX-0046 TPX0046
TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay.
Ret V804M-IN-1 Chemical Structure
 BCP37566 Ret V804M-IN-1 2414909-94-5
Ret V804M-IN-1 is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM.
cis-Pralsetinib Chemical Structure
 BCP31224 cis-Pralsetinib 2097132-93-7
cis-Pralsetinib is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.
Chemical Structure
 BCP30970 2222755-14-6
LOXO-292 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .
Pralsetinib Chemical Structure
 BCP29411 Pralsetinib 2097132-94-8
Pralsetinib (BLU-667) is a highly potent and selective RET inhibitor with an IC50 of 0.4 nM for wild type RET kinase.
RET Kinase inhibitor 1  Chemical Structure
 BCP23560 RET Kinase inhibitor 1  1627856-64-7
GSK3179106 is a potent, selective, first-in-class and gut-restricted RET kinase inhibitor with IC50 of 0.4 and 11 nM in the biochemical assay and cellular assay respectively, 273-fold selectivity over KDR.
AD80 Chemical Structure
 BCP25106 AD80 1384071-99-1
AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity.
AST-487 Chemical Structure
 BCP21589 AST-487 630124-46-8
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
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