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mAChR

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mAChR

Chemical Structure Cat. No. Product Name CAS No.
Emraclidine Chemical Structure
BCP48520 Emraclidine 2170722-84-4
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator.
VU0467154 Chemical Structure
BCP47001 VU0467154 1451993-15-9
VU0467154 is a potent and selective M4 PAM. VU0467154 exhibits robust APD-like and cognitive enhancing activity in rodents. Selective M4 PAMs could provide a therapeutic strategy for the treatment of HD.
Deschloroclozapine Chemical Structure
BCP46891 Deschloroclozapine 1977-07-7
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
Diphemanil Methylsulfate Chemical Structure
BCP44336 Diphemanil Methylsulfate 62-97-5
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic.It binds muscarinic acetycholine receptors (mAchR).
Nebracetam Chemical Structure
BCP44037 Nebracetam 116041-13-5
Nebracetam, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration.
Sofpironium bromide Chemical Structure
BCP43183 Sofpironium bromide 1628106-94-4
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.
VU0453595 Chemical Structure
BCP43186 VU0453595 1432436-13-9
VU0453595 is a novel M1 positive allosteric modulator (PAM), potential in schizophrenia.
Scopolamine hydrobromide trihydrate Chemical Structure
BCP40860 Scopolamine hydrobromide trihydrate 6533-68-2
Scopolamine is a competitive muscarinic acetylcholine receptor antagonist with IC50 value of 55.3 nM.
JHU37160 Chemical Structure
BCP40726 JHU37160 2369979-68-8
JHU37160 exhibits high in vivo DREADD occupancy and was not reported to be a P-gp substrate.
JHU37152 Chemical Structure
BCP40725 JHU37152 2369979-67-7
JHU37152 exhibits high in vivo DREADD occupancy and was not reported to be a P-gp substrate.
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