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Autophagy

Chemical Structure Cat. No. Product Name CAS No.
Curcumin analog C1 Chemical Structure
 BCP42914 Curcumin analog C1 39777-61-2
Curcumin analog C1 is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer's disease.
Apostatin-1 Chemical Structure
 BCP42606 Apostatin-1 2559703-06-7
Apostatin-1 is a novel TRADD inhibitor.
Indophagolin Chemical Structure
 BCP41936 Indophagolin 1207660-00-1
Indophagolin is a potent autophagy inhibitor with and IC50 value of 140 nM. Indophagolin also shows activity on the purinergic receptors with IC50 values of 2.40 μM, 3.49 μM and 2.71 μM for the P2X1, P2X3 and P2X4 receptors, respectively.
MK-8719 Chemical Structure
 BCP41252 MK-8719 1382799-40-7
MK-8719 is a selective and potent small molecule inhibitor of the O-GlcNAcase (OGA) enzyme with ki of 7.9nM for hOGA.
PHY34 Chemical Structure
 BCP39986 PHY34 2130033-55-3
PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM).
ULK-101 Chemical Structure
 BCP37780 ULK-101 2443816-45-1
ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM.
SR9011 Chemical Structure
 BCP37352 SR9011 1379686-29-9
SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
Vacuolin-1 Chemical Structure
 BCP35743 Vacuolin-1 351986-85-1
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.
Urolithin A Chemical Structure
 BCP35737 Urolithin A 1143-70-0
Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis.
YM-155 hydrochloride Chemical Structure
 BCP35549 YM-155 hydrochloride 355406-09-6
YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
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