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Angiogenesis/Protein Tyrosine Kinase
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FAK

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FAK

Chemical Structure Cat. No. Product Name CAS No.
GSK215 Chemical Structure
BCP46447 GSK215 2743427-26-9
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader.
AMP-945 Chemical Structure
BCP45164 AMP-945 1393653-34-3
AMP945 is an inhibitor of the enzyme focal adhesion kinase (FAK) that plays a key role in the formation of scar tissue (fibrosis) both in cancer and diseases like IPF.
PF-562271 HCl Chemical Structure
BCP42811 PF-562271 HCl 939791-41-0
PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities.
Y15 tetrahydrochloride Chemical Structure
BCP27854 Y15 tetrahydrochloride 4506-66-5
Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth.
BI-4464 Chemical Structure
BCP30859 BI-4464 1227948-02-8
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC.
PF 4618433 Chemical Structure
BCP29572 PF 4618433 1166393-85-6
PF 4618433 is an inhibitor of proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK).
Y 11 Chemical Structure
BCP28812 Y 11 1086639-59-9
Y11 is a small molecule inhibitor targeting Y397 site of FAK.
Repotrectinib Chemical Structure
BCP19778 Repotrectinib 1802220-02-5
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
CEP-37440 Chemical Structure
BCP13227 CEP-37440 1391712-60-9
CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
PF-562271 benzenesulfonate Chemical Structure
BCP14770 PF-562271 benzenesulfonate 939791-38-5
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 13 nM, and has > 100-fold selectivity against other protein kinases, except for some CDKs.
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