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Histone Demethylase

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Histone Demethylase

Chemical Structure Cat. No. Product Name CAS No.
JQKD-82 Chemical Structure
BCP44757 JQKD-82 2410512-38-6
JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM).
Bomedemstat Chemical Structure
BCP45548 Bomedemstat 1990504-34-1
Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antagonist BCLXL.
TAK-418 Chemical Structure
BCP44939 TAK-418 1818252-53-7
TAK-418 is a novel inhibitor of the epigenetic modulator lysine-specific demethylase 1A (LSD1).
KDM2A/7A-IN-1 Chemical Structure
BCP44938 KDM2A/7A-IN-1 2169272-46-0
KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases.
Bomedemstat ditosylate Chemical Structure
BCP44102 Bomedemstat ditosylate 1990504-72-7
Bomedemstat is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity.
Pulrodemstat Chemical Structure
BCP44101 Pulrodemstat 1821307-10-1
Pulrodemstat is a potent and orally active LSD1 inhibitor. CC-90011 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.
PFI-90 Chemical Structure
BCP42958 PFI-90 53995-62-3
PFI-90 is a selective inhibitor of the histone demethylase KDM3B.
DDP-38003 2HCl Chemical Structure
BCP39854 DDP-38003 2HCl 1831167-98-6
DDP-38003 2HCl is an orally available inhibitor of histone lysine-specific demethylase 1A (LSD1).
KDM5-IN-1 Chemical Structure
BCP37630 KDM5-IN-1 1628210-26-3
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor.
KDM5-C70 Chemical Structure
BCP37627 KDM5-C70 1596348-32-1
KDM5-C70 is a JARID1 Histone Demethylases Inhibitor. KDM5-C70 had an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels.
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