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PLK

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PLK

Chemical Structure Cat. No. Product Name CAS No.
TC-S 7005 Chemical Structure
 BCP48202 TC-S 7005 1082739-92-1
TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor.
Poloxin Chemical Structure
 BCP45204 Poloxin 321688-88-4
Poloxin is the first small-molecule inhibitor specifically targeting the function of the Plk1 PBD.
ON1231320 Chemical Structure
 BCP40722 ON1231320 1312471-39-8
ON1231320 is a potent selective inhibitor of Polo like kinase 2 (PLK2).
GW843682X Chemical Structure
 BCP27639 GW843682X 660868-91-7
GW843682X is a cell-permeable thiophene-benzimidazole compound that acts a selective PLK1 and PLK3 inhibitor with IC50s of 2.2 nM(PLK1) and 9.1 nM(PLK3).
DAP-81 Chemical Structure
 BCP29728 DAP-81 794466-17-4
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules.
CFI-400437 Chemical Structure
 BCP29569 CFI-400437 1247000-76-5
CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM).
ON1231320 Chemical Structure
 BCP19609 ON1231320 131247-39-8
ON1231320, also known as GBO-006, is a Polo-like kinase 2 (PLK2) inhibitor.
SBE 13 hydrochloride Chemical Structure
 BCP23836 SBE 13 hydrochloride 1052532-15-6
SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM).
Mps1-in-2 Chemical Structure
 BCP19164 Mps1-in-2 1228817-38-6
Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.
RO3280 Chemical Structure
 BCP07189 RO3280 1062243-51-9
Ro5203280 is a small-molecular PLK1 inhibitor that is structurally similar to BI2536, but with improved activity.
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