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Protease/Metabolic Enzyme
E1 E2 E3 Enzyme

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E1 E2 E3 Enzyme

Chemical Structure Cat. No. Product Name CAS No.
Cbl-b-IN-3 Chemical Structure
BCP49568 Cbl-b-IN-3 2573775-59-2
Cbl-b-IN-3 is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM.
BC-1382 Chemical Structure
BCP47333 BC-1382 1013753-99-5
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor which specifically disrupts the HECTD2/PIAS1 interaction.
Ubiquitination-IN-1 Chemical Structure
BCP46940 Ubiquitination-IN-1 1819330-15-8
Ubiquitination-IN-1 is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50 =0.17 μM) inhibitor.
M435-1279 Chemical Structure
BCP46473 M435-1279 1359431-16-5
M435-1279 is a UBE2T inhibitor.
NSC697923 Chemical Structure
BCP45754 NSC697923 343351-67-7
NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.
NSC232003 Chemical Structure
BCP44628 NSC232003 1905453-18-0
NAcM-OPT Chemical Structure
BCP35044 NAcM-OPT 2089293-61-6
NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM
CC-92480 Chemical Structure
BCP32805 CC-92480 2259648-80-9
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity.
DKM 2-93 Chemical Structure
BCP32598 DKM 2-93 65836-72-8
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.
COH000 Chemical Structure
BCP31057 COH000 1534358-79-6
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro.
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