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Angiogenesis/Protein Tyrosine Kinase

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Chemical Structure Cat. No. Product Name CAS No.
DCC-2036 Chemical Structure
BCP02345 DCC-2036 1020172-07-9
DCC-2036, potently inhibits both unphosphorylated and phosphorylated ABL1 by inducing a type II inactive conformation.
SU11274 Chemical Structure
BCP01778 SU11274 658084-23-2
SU11274 is selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro).
ACTB-1003 Chemical Structure
BCP13578 ACTB-1003 939805-30-8
ACTB-1003 is a potent inhibitor of FGFR1 with IC50 <10 nM in FGFR-1 biochemical assay; more information can be find in Patent WO/2007/064883A2.
Altiratinib Chemical Structure
BCP15682 Altiratinib 1345847-93-9
Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.
Cabozantinib L-Malate Salt Chemical Structure
BCP09448 Cabozantinib L-Malate Salt 1140909-48-3
A orally available and potent inhibitor of multiple receptor tyrosine kinases (RTK), specifically MET and VEGFR2. It also inhibits KIT, FLT3, Tie-2, RET and AXL.
Pexmetinib Chemical Structure
BCP28410 Pexmetinib 945614-12-0
Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.
MGCD-265 analog Chemical Structure
BCP02390 MGCD-265 analog 875337-44-3
MGCD-265-analog (structurally related to MGCD-265) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively.
Glesatinib hydrochloride Chemical Structure
BCP18872 Glesatinib hydrochloride 1123838-51-6
Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered.
Tie2-IN-5 Chemical Structure
BCP23755 Tie2-IN-5 948557-43-5
Tie2-IN-5 is a reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor.
AMG-Tie2-1 Chemical Structure
BCP01978 AMG-Tie2-1 870223-96-4
AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM).