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STING

Chemical Structure Cat. No. Product Name CAS No.
Cyclic-di-GMP Chemical Structure
 BCP25154 Cyclic-di-GMP 61093-23-0
Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species.
c-di-AMP disodium Chemical Structure
 BCP48318 c-di-AMP disodium 2734909-87-4
c-di-AMP sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.
c-di-AMP Chemical Structure
 BCP25152 c-di-AMP 54447-84-6
Cyclic-di-AMP (c-di-AMP) is a second messenger molecule produced in bacteria but not in mammals; can induce a strong immune response in vitro and in vivo.
CL656 Chemical Structure
 BCP47241 CL656 1951464-79-1
CL656 is an activator of stimulator of interferon genes (STING).
IACS-8779 Chemical Structure
 BCP47240 IACS-8779 2243079-26-5
IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy.
STING activator Compound 53 Chemical Structure
 BCP47281 STING activator Compound 53 2259624-71-8
STING activator Compound 53 is a potent, orally active human STING activator with an EC50 of 185 nM.
E7766 Chemical Structure
 BCP40761 E7766 2242635-02-3
E7766 is a STING agonist.
ChX710 Chemical Structure
 BCP39194 ChX710 2438721-44-7
ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF).
MSA-2 Chemical Structure
 BCP35448 MSA-2 129425-81-6
MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively.
SR-717 free acid Chemical Structure
 BCP35922 SR-717 free acid 2375420-34-9
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity.
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