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CaSR

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CaSR

Chemical Structure Cat. No. Product Name CAS No.
Etelcalcetide Chemical Structure
 BCP25088 Etelcalcetide 1262780-97-1
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.
TNCA Chemical Structure
 BCP48482 TNCA 42438-90-4
TNCA is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.
Evocalcet Chemical Structure
 BCP33803 Evocalcet 870964-67-3
Evocalcet is an orally available calcium receptor (CaR) modulator, with potential calcimimetic activity. Upon administration, evocalcet allosterically binds to and inhibits the activity of CaR, thereby suppressing the production of serum parathyroid hormone (PTH) and prevents the PTH-mediated efflux of calcium from bone and normalizes calcium levels.
Etelcalcetide HCl Chemical Structure
 BCP25093 Etelcalcetide HCl 1334237-71-6
Etelcalcetide, also known as AMG 416 and KAI-4169, is a D-amino peptide calcimimetic undergoing clinical evaluation for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis.
Ronacaleret HCl Chemical Structure
 BCP11469 Ronacaleret HCl 702686-96-2
Ronacaleret, also known as SB751689, is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)).
SB-423562 Chemical Structure
 BCP29936 SB-423562 351490-27-2
SB-423562 is a short-acting calcium-sensing receptor (CaR) antagonist.
Strontium chloride Chemical Structure
 BCP28245 Strontium chloride 10025-70-4
Calcium sensing receptor (CaSR) agonist. Activates ERK1/2 signaling, intracellular calcium mobilization, and calcitonin secretion. Enhances osteogenic differentiation of mesenchymal stem cells.
Cinacalcet Chemical Structure
 BCP07181 Cinacalcet 226256-56-0
AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism.
(S)-Cinacalcet hydrochloride Chemical Structure
 BCP12457 (S)-Cinacalcet hydrochloride 1217809-88-5
Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Ent-Cinacalcet Hydrochloride Chemical Structure
 BCP14361 Ent-Cinacalcet Hydrochloride 694495-47-1
Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
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