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Chemical Structure Cat. No. Product Name CAS No.
CB-839 Chemical Structure
BCP28287 CB-839 1439399-58-2
CB-839 is a potent and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC), and with IC50s of 23 nM and 28 nM in kidney and brain, respectively.
Mirdametinib Chemical Structure
BCP01841 Mirdametinib 391210-10-9
Mirdametinib, also known as PD-0325901, is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity.
Ponatinib Chemical Structure
BCP02037 Ponatinib 943319-70-8
Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN.
GDC-0941 Chemical Structure
BCP01714 GDC-0941 957054-30-7
Pictilisib, also known as Pictrelisib, GDC-0941, RG7321 and GNE0941 , is an orally bioavailable, and is a potent small-molecule thieno[3,2-d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) isoforms p100alpha and p100delta with potential antineoplastic activity.
Orantinib Chemical Structure
BCP01984 Orantinib 252916-29-3
TSU-68 (SU6668)is a novel multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 μM, 8 nM and 1.2 μM for VEGF-R1, PDGF-Rβ and FGF-R1, respectively.
Lapatinib Chemical Structure
BCP01874 Lapatinib 231277-92-2
Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
Camptothecin Chemical Structure
BCP02857 Camptothecin 7689-03-4
Camptothecin is a potent DNA enzyme topoisomerase I inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.
LY294002 Chemical Structure
BCP00195 LY294002 154447-36-6
LY294002 is a highly selective inhibitor of phosphatidylinositol 3-kinase.
Rapamycin Chemical Structure
BCP01404 Rapamycin 53123-88-9
Rapamycin is antifungal and immunosuppressant and specific inhibitor of mTOR.
Cabazitaxel Chemical Structure
BCP27641 Cabazitaxel 183133-96-2
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
Plerixafor Chemical Structure
BCP02337 Plerixafor 110078-46-1
Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
Empagliflozin Chemical Structure
BCP06962 Empagliflozin 864070-44-0
Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes.
CL2A-SN-38 Chemical Structure
BCP32728 CL2A-SN-38 1279680-68-0
CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).
Cintirorgon Chemical Structure
BCP28882 Cintirorgon 2055536-64-4
Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist.
Vandetanib Chemical Structure
BCP01925 Vandetanib 443913-73-3
Vandetanib is a multi-kinase inhibitor that is used in the therapy of advanced or metastatic medullary thyroid cancer. Vandetanib therapy is commonly associated with transient elevations in serum aminotransferase during therapy, but has not been linked to cases of clinically apparent acute liver injury with jaundice.
ABT-737 Chemical Structure
BCP01725 ABT-737 852808-04-9
ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts.
U0126-EtOH Chemical Structure
BCP05458 U0126-EtOH 1173097-76-1
U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. This inhibition of MEK1/2 is noncompetitive with ERK and ATP.
Afatinib Chemical Structure
BCP04467 Afatinib 850140-72-6
Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.
AZD8055 Chemical Structure
BCP02171 AZD8055 1009298-09-2
AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
Sofosbuvir Chemical Structure
BCP06035 Sofosbuvir 1190307-88-0
PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection.
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