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DNA/RNA Synthesis

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DNA/RNA Synthesis

Chemical Structure Cat. No. Product Name CAS No.
Bersiporocin dihydrochloride Chemical Structure
 BCP49201 Bersiporocin dihydrochloride 2241808-53-5
Bersiporocin is a prolyl-tRNA synthetase inhibitor.
DDD85646 Chemical Structure
 BCP28646 DDD85646 1215010-55-1
DDD85646 is a potent inhibitor of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nm; hNMTIC50=4 nm). The enzyme N-myristoyltransferase (NMT) is a potential drug target for human African trypanosomiasis.
AVN-944 Chemical Structure
 BCP23877 AVN-944 297730-17-7
AVN944 is a biotech drug that demonstrated a statistically meaningful impact on IMPDH and other proteins that are critical to activities in cancer cells, including nucleotide biosynthesis, energy and metabolism, DNA replication, apoptosis and cell cycle control. AVN944 has been associated with cancer cell death in clinical trials. It is being investigated for the treatment of patients with advanced hematologic malignancies.
Zinostatin Chemical Structure
 BCP48970 Zinostatin 9014-02-2
Zinostatin is a cytotoxic enediyne that alkylates DNA and RNA like mitomycin does. It has antineoplastic and antibiotic properties. It is isolated from the bacterium Streptomyces carzinostaticus. It may be active against hepatocellular carcinoma.
Bractoppin Chemical Structure
 BCP48934 Bractoppin 2290527-07-8
Bractoppin is a potent and selective drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response.
DDTT Chemical Structure
 BCP25080 DDTT 1192027-04-5
DDTT as a novel efficient sulfur transfer reagents suitable for DNA and RNA synthesis.
POL1-IN-1 Chemical Structure
 BCP25090 POL1-IN-1 1822358-25-7
POL1-IN-1 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0.5 uM.
JH-RE-06 Chemical Structure
 BCP48872 JH-RE-06 1361227-90-8
JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).
Diguanosine-5'-triphosphate Chemical Structure
 BCP48485 Diguanosine-5'-triphosphate 6674-45-9
Diguanosine 5′-triphosphate is a dinucleoside triphosphates.
T2AA Chemical Structure
 BCP48541 T2AA 1380782-27-3
T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor that inhibits PCNA/PIP-box peptide interaction and causes DNA replication stress by stalling DNA replication forks. It inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. It also suppresses cancer cell growth.
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