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Bcl2

Chemical Structure Cat. No. Product Name CAS No.
(R)-MIK665 Chemical Structure
 BCP47788 (R)-MIK665 1799831-02-9
(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special Mcl-1 inhibitor with an IC50 of 1.81 nM.
Lisaftoclax Chemical Structure
 BCP47569 Lisaftoclax 2180923-05-9
Lisaftoclax exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells.
SMBA1 Chemical Structure
 BCP45276 SMBA1 906440-37-7
SMBA1 is a selective acrivator of Bax, a central death regulator. It acts by potently suppressing lung tumour growth via apoptosis.
BI-3802 Chemical Structure
 BCP41514 BI-3802 2166387-65-9 
BI-3802 is a BCL6 inhibitor, with an IC50 of ≤3 nM. BI-3802 shows an IC50 of 43 nM for the cellular BCL6.
Mcl1-IN-2 Chemical Structure
 BCP40301 Mcl1-IN-2 292057-76-2
Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.
APG-2575 Chemical Structure
 BCP40069 APG-2575 APG2575
APG-2575 is a novel, orally administered small-molecule Bcl-2‒selective inhibitor.
BDA-366 Chemical Structure
 BCP39785 BDA-366 1909226-00-1
BDA-366 is a small-molecule Bcl2-BH4 domain antagonist, BDA-366, that binds BH4 with high affinity and selectivity.
S55746 Chemical Structure
 BCP39114 S55746 1448584-12-0
S55746 is an orally available BCL-2 specific inhibitor (Ki = 1.3 nM), displaying 70 to 400-fold selectivity for BCL-2 over BCL-XL.
Bcl-2-IN-2 Chemical Structure
 BCP36375 Bcl-2-IN-2 2383085-86-5
Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL.
BCL2 Degrader C5 Chemical Structure
 BCP36383 BCL2 Degrader C5 2378801-85-3
BCL2 Degrader C5 is a novel potent and selective degrader of Bcl-2.
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