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mTOR

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mTOR

Chemical Structure Cat. No. Product Name CAS No.
Panulisib Chemical Structure
 BCP44105 Panulisib 1356033-60-7
Panulisib is an orally bioavailable inhibitor of phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), activin receptor-like kinase 1 (ALK-1) and DNA-dependent protein kinase (DNA-PK), with potential anti-angiogenic and antineoplastic activities.
RapaLink-1 Chemical Structure
 BCP25153 RapaLink-1 1887095-82-0
RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors.
NV-5138 Chemical Structure
 BCP39080 NV-5138 2095886-80-7
NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2.
MT 63-78 Chemical Structure
 BCP38015 MT 63-78 1179347-65-9
MT 63-78 is a direct activator of AMPK, and an inhibitor of prostate cancer growth by blocking lipogenesis.
MTI-31 Chemical Structure
 BCP36715 MTI-31 1567915-38-1
MTI-31 is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.
PI-103 Hydrochloride Chemical Structure
 BCP36117 PI-103 Hydrochloride 371935-79-4
PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.
Rapalink-1 Chemical Structure
 BCP33282 Rapalink-1 Rapalink-1
RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (a second-generation mTOR kinase inhibitor) by an inert chemical linker.
AZD8055 Fumaric acid Chemical Structure
 BCP25958 AZD8055 Fumaric acid 1201799-05-4
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
AZD8055 D(-)-Tartaric Acid Chemical Structure
 BCP25959 AZD8055 D(-)-Tartaric Acid 1201799-04-3
AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2.
mTOR inhibitor-1 Chemical Structure
 BCP32690 mTOR inhibitor-1 468747-17-3
mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
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