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Raw Materials
PI3K/Akt/mTOR
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP46433 | PI-273 New | 925069-34-7 |
PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor. It can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
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BCP46378 | Gilmelisib New | 1845777-61-8 |
Gilmelisib is a PI3K inhibitor and antineoplastic.
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BCP46226 | GSK251 New | 2125968-05-8 |
GSK251 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode.
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BCP46023 | NV-5138 hydrochloride New | NV5138HCl |
NV-5138 (hydrochloride), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 (hydrochloride) is used for antidepressant studies.
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BCP45165 | ETP-45658 New | 1198357-79-7 |
ETP-45658 is a PI3-kinase inhibitor, also ihibiting DNA-PK and mTOR.
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BCP44964 | PF-04802367 New | 1962178-27-3 |
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.
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BCP44636 | BAY8400 New | BAY8400 |
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer.
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BCP44337 | IM156 New | 1422365-94-3 |
IM156, a chemical derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model.
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BCP44115 | GS-9901 New | 1640247-87-5 |
GS-9901 is a potent, orally active and highly selective inhibitor of PI3Kδ (PI3Kdelta IC50 = 1.0nM, HWB delta EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.).
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BCP44105 | Panulisib New | 1356033-60-7 |
Panulisib is an orally bioavailable inhibitor of phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), activin receptor-like kinase 1 (ALK-1) and DNA-dependent protein kinase (DNA-PK), with potential anti-angiogenic and antineoplastic activities.
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